Publications by authors named "L Mramba"
Purpose: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years.
Methods: We followed 8500 T1D-susceptible children born in the U.S.
Background: Outliers can influence regression model parameters and change the direction of the estimated effect, over-estimating or under-estimating the strength of the association between a response variable and an exposure of interest. Identifying visit-level outliers from longitudinal data with continuous time-dependent covariates is important when the distribution of such variable is highly skewed.
Objectives: The primary objective was to identify potential outliers at follow-up visits using interquartile range (IQR) statistic and assess their influence on estimated Cox regression parameters.
Article Synopsis
- Higher gluten intake in childhood is linked to a greater risk of celiac disease autoimmunity (CDA) and celiac disease, but other dietary patterns may also play a role.
- The study analyzed data from 6,726 genetically susceptible children, examining their diets at age 2 to see how it affects the likelihood of developing CDA and celiac disease as they grew older.
- Results showed that a diet rich in vegetable fats and milk at 9 months was protective against CDA, whereas a diet high in wheat and vegetable fats at 24 months increased the risk of both CDA and celiac disease.
Objective: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).
Research Design And Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.
Background: With growing resident burnout, Accreditation Council for Graduate Medical Education issued new requirements for program interventions to optimize resident well-being. Little evidence exists on how to best teach resiliency to residents. This study assesses the impact of both a grassroots intervention and formal resiliency curriculum on resident burnout and well-being.
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