Clinical Manifestations.

Background: The Clinical Dementia Rating Sum of Boxes (CDR-SB) is a widely used measurement score to stage dementia severity; it has become one of the most common outcome measurements in Alzheimer's Disease (AD) research. The CDR-SB requires an informant to provide information to stage a patient's dementia severity. The effect of the informant's characteristics including sex and relationship with patients on the CDR-SB is unknown.

Extraction of compression indices from maternal-fetal heart rate simultaneous signals.

Intrapartum asphyxia is responsible for approximately 900 000 deaths per year worldwide. These numbers show the urgency of investing in the quality of fetal health care. The heart rate signal is a complex signal and sometimes behaves unpredictably.

Longitudinal analysis of hospital morbidity and mortality due to skin cancer from 2012 to 2022: comparison with demographic and geographic factors in Brazilian states.

Background: Skin cancer is the most common neoplasm among Brazilians, accounting for 31.3% of all cancer cases in the country.

Objectives: To analyze the longitudinal morbimortality of skin cancer and compare it with the latitude and the prevalence of white skin color in each federative unit of the country.

Safety and Efficacy of Moderate-Dose Denosumab in Fibrous Dysplasia: Observational Results from a Phase 2 Clinical Trial.

Context: Fibrous dysplasia (FD) is a rare skeletal mosaic disease associated with fractures and disability. A phase 2 trial of the RANKL inhibitor denosumab (NCT03571191) reported profound reductions in lesion activity and increased lesional mineralization after 6-months of high-dose treatment. Denosumab was well-tolerated, however discontinuation was associated with severe hypercalcemia.

Asymptomatic carriage of intestinal protists is common in children in Lusaka Province, Zambia.

Background: PCR-based screenings on the presence of diarrhoea-causing intestinal protist species are limited in Zambia, resulting in inaccurate current prevalence and epidemiological data. Sensitive PCR-based methods are particularly well suited for detecting subclinical infections in apparently healthy carriers.

Methodology: In this prospective cross-sectional study, we investigated the occurrence of the most common intestinal protists in an apparently healthy paediatric population (5-18 years) in Lusaka Province, Zambia.