Publications by authors named "L Mott"
Nicotine is the primary addictive component of tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. To assess the underlying mechanisms, we treated rabbits with transdermal nicotine (NIC, 21 mg/day) or control (CT) patches for 28 days before performing dual optical mapping of transmembrane potential (RH237) and intracellular Ca (Rhod-2 AM) in isolated hearts with intact sympathetic innervation.
View Article and Find Full Text PDFUnlabelled: Nicotine is the primary addictive component in tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. However, the underlying mechanisms are unclear.
View Article and Find Full Text PDFPolymer/Nanoceria Hybrid Polyplexes for Gene and Antioxidant Delivery.
ACS Appl Bio Mater
August 2023
Various diseases, including cancers and inflammatory diseases, are characterized by a disruption of redox homeostasis, suggesting the need for synergistic treatments involving co-delivery of gene therapies and free radical scavengers. In this report, polyethylenimine (PEI), nanoceria (NC), and DNA were complexed to form nanoparticles providing simultaneous delivery of a gene and an antioxidant. NC was coated in citric acid to provide stable, 4 nm particles that electrostatically bound PEI/DNA polyplexes.
View Article and Find Full Text PDFPlasma Metabolomics Analysis of Aspirin Treatment and Risk of Colorectal Adenomas.
Cancer Prev Res (Phila)
August 2022
Article Synopsis
- Research shows aspirin may help prevent colorectal neoplasia, but the molecular mechanisms behind this effect are not well understood, limiting its safe and effective use.
- A study used untargeted plasma metabolomics on 523 participants from a clinical trial to identify metabolites associated with aspirin treatment and reduced adenoma risk over three years.
- Key findings highlighted that specific metabolites related to linoleate and lysophospholipids increased with low-dose aspirin and were linked to a decreased risk of adenomas, suggesting new insights into aspirin's preventive effects.
Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Cancer Epidemiol Biomarkers Prev
May 2022
Background: Serrated polyps (SP) are important colorectal cancer precursors, yet their epidemiology is incompletely understood. We measured risk factors for incident sessile-serrated lesions (SSL) and microvesicular (MVHP) and goblet-cell rich (GCHP) hyperplastic polyp subtypes.
Methods: We conducted a cohort study of patients undergoing colonoscopic surveillance nested within a chemoprevention trial.