Publications by authors named "L Moreira"
Compound (4-(3,5-di-tert-butyl-4-hydroxybenzylamine)benzenesulfonamide) (LQFM275) was designed and synthesized from darbufelone and sulfanilamide as a new multi-target for the treatment of inflammatory diseases. LQFM275 showed a great range of safe cytotoxicity profile (100-400 μM) evaluated by MTT assay, preventing damage induced by lipopolysaccharide (LPS) in EA.hy926 cell line.
View Article and Find Full Text PDFCharacteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry.
BMC Infect Dis
December 2024
Article Synopsis
- The Covid-19 pandemic adversely affected the management of other infectious diseases, especially in low and middle-income countries, leading to concerns about diseases like tuberculosis.
- A matched case-control study compared Covid-19 effects in patients with prior tuberculosis against those without, using data from Brazilian hospitals over two years.
- Results showed the tuberculosis group had higher rates of several comorbidities and medication usage but did not experience more severe outcomes like higher in-hospital mortality or need for intensive care compared to the control group.
Extremophile organisms have been largely studied in Astrobiology. Among them, two antarctic plants emerge as good candidates to become colonizers of other celestial bodies, such as Mars and the Moon. The present research aimed to evaluate survival and growing capacity of Sanionia uncinata and Colobanthus quitensis on Martian (MGS-1) and Lunar (LMS-1) regolith simulants, under terrestrial conditions.
View Article and Find Full Text PDFArticle Synopsis
- A high-fat and high-fructose diet can alter gut microbiota and lead to metabolic changes, while chia oil contains beneficial alpha-linolenic acid with potential gut health benefits.
- In an experiment with rats, those on a high-fat diet supplemented with chia oil showed increased levels of immunoglobulin A and short-chain fatty acids, indicating improved intestinal health.
- Despite the benefits of chia oil, the overall diversity of gut microbiota remained unchanged, but certain beneficial bacterial genera were more prevalent in rats consuming chia oil compared to standard diets.
: The Brazilian health system provides healthcare financed by the public and private sector, being the first designed to encompass universal healthcare coverage delivered to the population without charge to patients (Sistema Único de Saúde, SUS), whilst the second refers to healthcare coverage delivered for individuals with the capacity to pay for assistance through health insurance or out-of-pocket disbursements. Health insurance companies with beneficiaries receiving publicly financed healthcare from the SUS are required to provide the reimbursement of healthcare expenditures to the government, considering that the health insurance beneficiaries obtain deductions of income taxes designed to fund the SUS. Therefore, the study investigated patterns of healthcare utilization and public expenditure due to the use of public healthcare by beneficiaries of health insurance between 2003 and 2019.
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