Publications by authors named "L Morbidoni"
Article Synopsis
- - The document reviews recent studies and international guidelines to provide updated recommendations for internists managing acute heart failure (AHF) in complex patient scenarios.
- - Seven key clinical questions (PICOs) were identified regarding diagnosis and treatment, emphasizing the importance of echocardiography and natriuretic peptide evaluations, along with other diagnostic tools.
- - A total of 51 tailored recommendations were developed to address treatment strategies and improve outcomes for AHF patients, including options for managing low blood pressure and preventing rehospitalization.
Medical divisions are at high risk of Clostridioides difficile infection (CDI) due to patients' frailty and complexity. This sub-analysis of the FADOI-PRACTICE study included patients presenting with diarrhea either at admission or during hospitalization. CDI diagnosis was confirmed when both enzyme immunoassay and A and B toxin detection were found positive.
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- This document reviews recent trials and updates international clinical practice guidelines (CPGs) to help doctors make decisions about diagnosing and treating acute pulmonary embolism (PE) in complex cases.
- The authors identified five specific clinical issues related to PE and evaluated existing CPGs to create tailored recommendations, such as preferred diagnostic methods and treatment protocols depending on patient conditions like pregnancy.
- Ultimately, the document provides 35 endorsed recommendations, aiming to simplify the decision-making process for clinicians managing patients with acute PE.
Background: Published reports on tocilizumab in COVID-19 pneumonitis show conflicting results due to weak designs or heterogeneity in critical methodological issues.
Methods: This open-label trial, structured according to Simon's optimal design, aims to identify factors predicting which patients could benefit from anti-IL6 strategies and to enhance the design of unequivocal and reliable future randomized trials. A total of 46 patients with COVID-19 pneumonia needing of oxygen therapy to maintain SO2 > 93% and with recent worsening of lung function received a single infusion of tocilizumab.