Publications by authors named "L Morand-Joubert"
We report a case of persistent disseminated mpox evolving over >6 months in an HIV/hepatitis B virus co-infected patient in France who had <200 CD4+ cells/mm, pulmonary and hepatic necrotic lesions, persistent viremia, and nasopharyngeal excretion. Clinical outcome was favorable after 90 days of tecovirimat treatment and administration of human vaccinia immunoglobulins.
View Article and Find Full Text PDFDue to shared routes of transmission, including sexual contact and vertical transmission, HIV-HBV co-infection is common, particularly in sub-Saharan Africa. Measurement of viral load (VL), for both HIV and HBV, plays a critical role for determining their infectious phase and monitoring response to antiviral therapy. Implementation of viral load testing in clinical settings is a significant challenge in resource-limited countries, notably because of cost and availability issues.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the immune response to SARS-CoV-2 after COVID-19 infection and vaccination, focusing on anti-RBD antibodies and functional neutralizing antibodies (NAbs).
- Researchers analyzed samples from different groups, including partially and fully vaccinated individuals as well as those who had COVID-19 with or without vaccination, using advanced testing methods.
- Results showed that the post-COVID/vaccination group had the strongest immune protection, with a clear link between antibody levels and neutralization ability, and the ichroma™ test proved effective in assessing immunity.
Article Synopsis
- This study investigates COVID-19-associated pulmonary aspergillosis (CAPA) among critically ill patients during the Omicron variant wave, finding it affects 5.1% of patients and 9.1% of those on invasive mechanical ventilation.
- CAPA patients showed higher rates of immunosuppression and required more intensive care measures, like vasopressors and renal therapy, compared to non-CAPA patients.
- While CAPA did not significantly impact day-28 mortality, it was linked to longer mechanical ventilation and ICU stays, suggesting a shift in outcomes with emerging SARS-CoV-2 variants.