Publications by authors named "L Montella"
Impact of Vitamin D Levels on Progression-Free Survival and Response to Neoadjuvant Chemotherapy in Breast Cancer Patients: A Systematic Review and Meta-Analysis.
Cancers (Basel)
December 2024
Breast cancer remains the leading cause of cancer-related deaths among women despite advances in early detection. Neoadjuvant chemotherapy (NACT) is now standard for early-stage BC, with vitamin D (VD) emerging as a potential prognostic biomarker considering its positive pleiotropic effects. This review and meta-analysis assess the impact of baseline VD levels on outcomes in BC patients undergoing NACT.
View Article and Find Full Text PDFBackground: Hormone receptor-positive tumors are unlikely to exhibit a complete pathological tumor response. The association of CDK 4/6 inhibitor plus hormone therapy has changed this perspective.
Case Presentation: In this study, we retrospectively reviewed the charts of patients with a diagnosis of luminal A/B advanced/metastatic tumors treated with a CDK 4/6 inhibitor-based therapy.
Article Synopsis
- SARS-CoV-2 vaccination is highly recommended for fragile patients, particularly those undergoing cancer treatments, and post-marketing surveillance is necessary for this group.
- The study analyzed data from 136 cancer patients who received mRNA vaccines (Pfizer-BioNTech and Moderna) and found significant occurrences of leukopenia after vaccination, especially in those receiving chemotherapy and chemo-immunotherapy.
- While a small portion of patients experienced treatment delays, the vaccine did not significantly disrupt treatment schedules, indicating the need for more extensive studies to better understand the vaccine's effects in this vulnerable population.
Article Synopsis
- Increased production of reactive oxygen species (ROS) during cellular injury can lead to conditions like cancer, with glutathione (GSH) playing a crucial role in restoring cellular balance.
- A review of clinical and preclinical data revealed that GSH can interact with anti-cancer drugs, either reducing their harmful effects or, conversely, increasing their toxicity through bioactivation.
- While many cancer patients self-prescribe GSH to mitigate treatment side effects, there’s limited scientific backing for its effectiveness, and it's recommended to use GSH only under medical guidance for safe administration.
Background: Vitamin D (VD) has been implicated in several diseases, including colorectal cancer (CRC). This study aimed to determine whether there is an association between VD levels and time-to-outcome in stage III CRC patients through a systematic review and meta-analysis.
Methods: The study adhered to the PRISMA 2020 statement.