Publications by authors named "L Molineaux"
Article Synopsis
- Human norovirus (HuNoV) causes over 700 million cases of gastroenteritis yearly, leading to symptoms like vomiting and diarrhea, but the mechanisms of infection are not well understood due to the absence of suitable animal models.
- Researchers utilized a zebrafish larvae model to investigate how HuNoV affects intestinal motility and whether a specific viral protein might act as an enterotoxin.
- The study found that HuNoV GII.4 infection increased intestinal contraction frequency and delayed food transit time in the larvae, indicating potential effects on bowel movements, with viral proteins VP1 and VP2 playing significant roles in these symptoms.
The intensity of Plasmodium falciparum transmission has multifarious and sometimes counter-intuitive effects on age-specific rates of severe morbidity and mortality in endemic areas. This has led to conflicting speculations about the likely impact of malaria control interventions. We propose a quantitative framework to reconcile the various apparently contradictory observations relating morbidity and mortality rates to malaria transmission.
View Article and Find Full Text PDFWe propose a stochastic model for simulating malaria tolerance. The model relates the probability of a clinical attack of malaria to the peripheral parasite densities via a pyrogenic threshold that itself responds dynamically to the parasite load. The parameters of the model have been estimated by fitting it to the relationship between incidence of clinical episodes and the entomologic inoculation rate, using age-specific incidence data from two villages in Senegal and one village in Tanzania.
View Article and Find Full Text PDFWe present a dynamic model of the highly pathogenic first wave of Plasmodium falciparum asexual parasitemia in non-immune persons. The model was successfully fitted to malaria therapy data. This required four case-specific parameters: the basic two-day multiplication factor, the time of onset of adaptive immunity, and the effective dose 50 densities for the innate and adaptive immune responses, respectively.
View Article and Find Full Text PDFMost mathematical models for acquired immunity to Plasmodium falciparum consider effects of immunity on duration of infection and infectiousness, but do not consider the most evident effect of immunity, which is to reduce parasite densities. Few attempts have been made to fit such models to field data. We propose a stochastic simulation model to predict the distributions of P.
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