Stereolithography of ceramic scaffolds for bone tissue regeneration: Influence of hydroxyapatite/silica ratio on mechanical properties.

In this paper, the results obtained in the development of ceramic resin feedstock for stereolithography are shown. Hydroxyapatite and silica are used as source of ceramic. Hydroxyapatite is extracted from bovine bone, which enhances bioactivity of ceramic scaffold.

CORRELATION OF BLOOD BIOCHEMICAL INDICATORS WITH THE LEVEL OF KNEE JOINT DAMAGE IN THE MODEL OF THE POSTTRAUMATIC OSTEOARTHRITIS.

The aim of the study was to assess the dependence of blood biochemical parameters with the degree of osteoarthritis of the knee joint and therapy. In experiments, osteoarthritis was simulated in rabbits (n=25) and after 75 days changes in the level of peroxidation products, activity of leukocyte enzymes were studied and the results were compared with the degree of knee joint injury, as well as taking into account the application of a concentrate of bone marrow aspirate, mechanically homogenized adipose tissue and platelet rich plasma. Analysis of the results confirmed the assumption of a direct relationship between the level of peroxidation products (diene conjugates, TBA-reactive products, products of oxidative modification of proteins), ceruloplasmin, and proinflammatory activity of leukocytes (by the activity of elastase and myeloperoxidase) with the level of morphological changes in the articular cartilage, capsule and meniscus of the knee joint.

Design of iodine-lithium-alpha-dextrin liquid crystal with potent antimicrobial and anti-inflammatory properties.

An ideal antimicrobial should be not toxic and possess board spectrum antiviral, antibacterial, antifungal activity, excluding resistance and should affect pathogen-mediated damage of host physiology including immune, nervous and endocrine systems. With the purpose of a combination of nonspecific antimicrobial action of molecular and ionized iodine with systemic immune-modulating property of the negatively charged polysaccharides a complex drug of iodine and lithium on a template of a alpha-dextrin liquid crystal was designed. The physicochemical model of iodine-lithium-alpha-dextrin (ILalphaD) is based on the human blood and the stereochemistry of moving equilibred systems of dynamically balanced organic polymers conformation complexed with the iodine and lithium molecules.

The 1F7 idiotype is selectively expressed on CD5+ B cells and elevated in chronic hepatitis C virus infection.

Antibodies against different chronic viruses, including hepatitis C virus (HCV), express a public cross-reactive idiotype (Id) designated as 1F7. The prominence of this Id may reflect selective engagement of B1 B cells by chronic pathogens. We investigated this by comparing 1F7 Id expression on CD5(+) and CD5(-) B cells, total IgG, total IgM and anti-HCV core antibodies in different HCV exposure settings.