Retrospective evaluation of an intervention bundle on OPAT implementation in a large non-university hospital.

Objectives: Optimization of outpatient parenteral antimicrobial therapy (OPAT) requires interdisciplinarity and an operational algorithm. This report retrospectively assesses the impact of a multimodal quality-enhancement intervention bundle on the implementation rate, efficacy, and safety of a home OPAT program in a Belgian large community-based hospital.

Methods: OPAT recipients between 1 March 2019 and 30 June 2022 were included.

Improving North Atlantic Marine Core Chronologies Using Th Normalization.

Producing independent and accurate chronologies for marine sediments is a prerequisite to understand the sequence of millennial-scale events and reveal potential temporal offsets between marine and continental records, or between different marine records, possibly from different regions. The last 40 ky is a generally well-constrained period since radiocarbon (C) can be used as an absolute dating tool. However, in the northern North Atlantic, calendar ages cannot be directly derived from C ages, due to temporal and spatial variations of surface reservoir ages.

Consistently dated Atlantic sediment cores over the last 40 thousand years.

Rapid changes in ocean circulation and climate have been observed in marine-sediment and ice cores over the last glacial period and deglaciation, highlighting the non-linear character of the climate system and underlining the possibility of rapid climate shifts in response to anthropogenic greenhouse gas forcing. To date, these rapid changes in climate and ocean circulation are still not fully explained. One obstacle hindering progress in our understanding of the interactions between past ocean circulation and climate changes is the difficulty of accurately dating marine cores.