Publications by authors named "L Milone"
Article Synopsis
- The study investigates how prematurity influences the methylation of the LINE-1 gene in neonates, with a focus on DNA samples taken at various days after birth.
- Researchers found that overall, premature infants had lower methylation levels at birth, but this difference reduced over time.
- Interestingly, extremely premature infants (born before 28 weeks) exhibited higher methylation levels, comparable to full-term babies, suggesting that prematurity significantly affects LINE-1 methylation patterns and highlighting the complexity of epigenetic effects.
Article Synopsis
- Hypersplenism is a condition where blood cells are destroyed rapidly, characterized by splenomegaly, cytopenias, and increased bone marrow activity, and can be secondary to diseases like sickle cell disease, specifically hemoglobin sickle C disease (HbSC).
- A 41-year-old woman with HbSC presented with complications from splenomegaly and anemia due to hypersplenism, leading to her undergoing a splenectomy after preoperative splenic artery embolization.
- Hypersplenism can lead to severe complications like splenic sequestration crises, affecting adults rarely but is associated with significant spleen enlargement, as demonstrated by the patient’s spleen measuring 21.1 cm, necessitating effective
Obstructive lower urinary tract symptoms in young men can occasionally be attributed to rare intra-prostatic cystic lesions. This case reports a 27-year-old man presenting with sudden onset voiding difficulty, diagnosed with a midline prostatic cyst at the anterior bladder neck, a rare location. The cyst was successfully treated with bipolar transurethral endoscopic resection, resulting in the resolution of urinary symptoms without retrograde ejaculation which is a common complication that is a central concern in the literature regarding the choice of surgical modality.
View Article and Find Full Text PDFBackground: The TAVAC and Pediatric Committees of SAGES evaluated the current use of mini-laparoscopic instrumentation to better understand the role this category of devices plays in the delivery of minimally invasive surgery today.
Methods: The role of mini-laparoscopic instrumentation, defined as minimally invasive instruments of between 1 and 4 mm in diameter, was assessed by an exhaustive review of the peer reviewed literature on the subject between 1990 and 2021. The instruments, their use, and their perceived value were tabulated and described.
Aim: We aimed to evaluate the knowledge, attitude, and practices in the application of AI in the emergency setting among international acute care and emergency surgeons.
Methods: An online questionnaire composed of 30 multiple choice and open-ended questions was sent to the members of the World Society of Emergency Surgery between 29th May and 28th August 2021. The questionnaire was developed by a panel of 11 international experts and approved by the WSES steering committee.