Relugolix combination therapy and symptoms of uterine myomatosis - selected case reports of indication spectrum and treatment outcomes.

Objective: An illustrative review of the indications for relugolix combination therapy (RCT) in the management of symptoms associated with uterine myomatosis.

Methods: A set of annotated case reports from outpatient and clinical practice.

Results: The file includes a non-invasive methodology for defining excessive menstrual bleeding using the pictorial bleeding assessment chart (PBAC).

Office hysteroscopic myomectomy without myoma extraction: A multicenter prospective study.

Objective: To evaluate the feasibility and safety of leaving the submucous myoma (SM) in the uterine cavity after office hysteroscopic enucleation.

Study Design: Prospective multicenter study including patients who had a single SM diagnosed by transvaginal ultrasounds with surgical indication. Office hysteroscopic enucleation of the SM was performed using a 5 mm continuous flow office hysteroscope with a 2.

[Relation between insulin resistance and amount of visceral adipose tissue].

Background: Association of obesity with metabolic and cardiovascular complications depends on the adipose tissue distribution. The role of intraabdominal, i.e.

Retinol-binding protein 4 expression in visceral and subcutaneous fat in human obesity.

Retinol binding protein 4 (RBP4) is a novel adipokine which might be involved in the development of insulin resistance. The aim of the study was to investigate the expression of RBP4 mRNA in subcutaneous and visceral fat depots and the relationship between RBP4 plasma and mRNA levels relative to indices of adiposity and insulin resistance. In 59 Caucasian women (BMI 20 to 49 kg/m(2)) paired samples of subcutaneous and visceral fat were obtained for RBP4, leptin and GLUT 4 mRNA analysis using reverse transcription-quantitative PCR.

Synergistic effect of ligating and ionic functions, prearranged on a calix[4]arene.

The covalent attachment of two CMPO-functions and two anionic Cosan groups to the narrow rim of tert-butylcalix[4]arene leads to a dramatic increase of the extraction efficiency for the cone isomer; Am(3+) is removed from 5 x 10(-8) M solution to more than 99% by a single extraction step with a 3 x 10(-6) M solution of the calixarene.