Publications by authors named "L Migliolo"
Article Synopsis
- - Defensins are found in various organisms and categorized into - and -defensins; recent studies have identified 74 new -defensins in bacteria and propose a new classification system for them.
- - The study presents the first NMR structure of a defensin known as Xanthusin-1, suggesting it may represent a unique group of defensins, with gene expression observed in specific growth media.
- - Findings indicate a broader distribution of defensins beyond eukaryotes, hinting at a prokaryotic origin for certain motifs, and show that both Gram-positive and Gram-negative bacteria possess defensins, indicating early evolutionary roots but also significant gene loss.
Healthcare-associated infections (HAIs) pose significant challenges to global health due to pathogen complexity and antimicrobial resistance. Biosensors utilizing antimicrobial peptides offer innovative solutions. Hylarana picturata Multiple Active Peptide 1 (Hp-MAP1), derived from Temporin-PTA, exhibits antibacterial properties sourced from the skin secretions of the Malaysian fire-bellied frog.
View Article and Find Full Text PDFIdentification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea.
Purinergic Signal
July 2024
Snake bites are a severe problem in the countryside of Brazil and are usually attributed to snakes of the genera Bothrops, Crotalus, and Lachesis. Snake venom can release ectoenzymes and nucleotidases that modulate the purinergic system. In addition to serum therapy against snake poisoning, medicinal plants with anti-inflammatory activities, such as Tabebuia aurea, is empirically applied in accidents that occur in difficult-to-access areas.
View Article and Find Full Text PDFEpilepsy represents a condition in which abnormal neuronal discharges or the hyperexcitability of neurons occur with synchronicity, presenting a significant public health challenge. Prognostic factors, such as etiology, electroencephalogram (EEG) abnormalities, the type and number of seizures before treatment, as well as the initial unsatisfactory effects of medications, are important considerations. Although there are several third-generation antiepileptic drugs currently available, their multiple side effects can negatively affect patient quality of life.
View Article and Find Full Text PDFArticle Synopsis
- Chagas disease, sleeping sickness, and malaria are serious infections caused by protozoan parasites that affect millions globally.
- In an experiment, synthetic polyalanine peptides were tested for their effectiveness against these parasites, showing that two specific peptides inhibited growth significantly.
- Structural analysis revealed that one peptide interacts more deeply with cell membranes, suggesting different mechanisms of action, which supports the idea of using these peptides as potential treatments for sleeping sickness.