Publications by authors named "L Micouin"
This study presents efficient synthetic pathways for preparing novel azaspirocycles. These methodologies involve functionalizing key bicyclic hydrazines with a substituent on one of their bridgehead carbon atoms. The desired spirocyclic cores were successfully obtained through double reductive amination reactions, intramolecular cyclizations, and cleavages of the N-N bond.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the coordination of lanthanide ions with paracyclophane derivatives, specifically five complexes made from a unique ligand that connects various lanthanides, including Dy(III) and Yb(III).
- Four mononuclear and one dinuclear complex were created and thoroughly characterized using methods like X-ray diffraction, spectroscopy, and magnetic measurements.
- These complexes show promising properties for luminescence and magnetic behavior, with some exhibiting single-molecule magnet characteristics under specific conditions.
α-Silylated diazoalkynes are stabilized diazo compounds that can selectively react with carboxylic residues in buffered aqueous media. In-situ fluoride induced desilylation increases this reactivity, leading to a very fast reaction. Application to the selective functionalization of RNase A, followed by post-functionalization using click chemistry, is described.
View Article and Find Full Text PDFHave spirocyclic scaffolds been properly utilized in recent drug discovery efforts?
Expert Opin Drug Discov
March 2024
Herein, we demonstrate for the first time that coumarins derived from [2.2]paracyclophane (pCp) can act as effective organo-photocatalysts and promote the reductive cleavage of sulfonamides under light-irradiation. In the presence of these original compounds, photodesulfonylation reactions occur under mild conditions at low catalyst loadings in the presence of Hantzsch ester.
View Article and Find Full Text PDF