Dynamic changes of live/apoptotic circulating tumour cells as predictive marker of response to sunitinib in metastatic renal cancer.

Background: Recently, we developed an apoptotic assay for expanding the monitoring capabilities of the circulating tumour cells (CTC) test during therapy. An automated platform for computing CTCs was integrated with a mAb (M30) targeting a neoepitope disclosed by caspase cleavage at cytokeratin 18 in early apoptosis; we showed that live CTCs were associated with progression, consistent with enhanced cell migration and invasion. The test was first applied here to mRCC.

Transformations of geometrical objects in middle Egyptian mathematical texts.

This paper analyzes the algorithmic structure of geometrical problems in Egyptian papyri of the first half of the second millennium B.C. Processes of transformation of quantities from "false" values into actual values, and conversions from quantities expressed in the abstract system of numbers into metrological quantities, are known in Egyptian mathematics.