Publications by authors named "L Meulemans"

A good stair-climbing (SC) ability is crucial for independent living in older adults. A simple formula that estimates the mean power needed to ascend a flight of stairs in a predetermined time (i.e.

View Article and Find Full Text PDF

Lower-limb muscle power should be closely monitored to prevent age-related functional ability declines. Stair-climbing (SC) power is a functionally relevant measurement of lower-limb muscle power. Body-fixed sensors can measure power production throughout the different steps of a flight of stairs to assess different aspects of performance.

View Article and Find Full Text PDF

Estimating lower-limb muscle power during sit-to-stand (STS) tests is feasible for large-scale implementation. This study investigated 1) whether age, functional limitations and sex have an influence on the movement strategy and power production during STS; and 2) potential differences between STS power estimated with either a simple equation or a sensor. Five-repetition STS data of 649 subjects (♂352 ♀297) aged 19 to 93 years were included.

View Article and Find Full Text PDF

Purpose: Five times sit-to-stand (STS) test is commonly used as a clinical assessment of lower-extremity functional ability, but its association with free-living performance has not been studied. Therefore, we investigated the association between laboratory-based STS capacity and free-living STS performance using accelerometry. The results were stratified according to age and functional ability groups.

View Article and Find Full Text PDF
Article Synopsis
  • Spliceogenic variants in genes linked to diseases are often thought to be harmful due to their tendency to cause frameshifts that lead to loss of function; however, some may only cause modifications that maintain function, as shown in recent studies of cancer predisposition genes.
  • This study focused on the DNA mismatch repair gene MSH2, relevant to Lynch syndrome, and used minigene splicing assays to analyze 18 variants primarily found at splice sites, assessing the resulting protein changes.
  • The findings revealed three types of RNA changes that produced altered protein isoforms, all of which disrupted MSH2 function, confirming their pathogenicity and highlighting the need for integrated RNA and protein analyses for accurate clinical evaluations of these variants.
View Article and Find Full Text PDF