Publications by authors named "L Mesnard"
Background: Alport Syndromes (AS) are the second leading genetic cause of Kidney Failure (KF). Whether multiple kidney cysts (MKC) phenotype belongs to the AS spectrum remains debated.
Methods: This multicenter retrospective study focused on patients genotyped with pathogenic COL4A3, COL4A4, or COL4A5 variants (classified as ACMG-AMP 4 or 5) between January 2011 and January 2023 across four French university hospitals.
Article Synopsis
- - This study reports the first isolation of a newly identified bacteria species from two patients in France suffering from gastroenteritis, using samples collected in 2020 and 2022.
- - Both isolates were confirmed to belong to the same species through various methods including biochemical tests, electron microscopy, and genetic analyses, and they exhibited significant cytopathogenic activity in human intestinal cells.
- - The findings highlight the importance of utilizing next-generation sequencing for accurate species identification. It underscores the need to recognize emerging pathogens like this new species as potential foodborne threats to public health.