Publications by authors named "L Mellor"
Article Synopsis
- The study aimed to create a predictive tool to determine which patients with mild traumatic brain injury (mTBI) and subdural hematoma (SDH) may need neurosurgical intervention, as current methods are unreliable and lead to unnecessary treatments.
- Conducted across six trauma centers, the research analyzed 1,333 patients admitted between 2016 and 2020, using variables like hematoma thickness and Glasgow Coma Scale scores to inform predictions.
- Results showed a neurosurgical intervention rate of 8.8%, with key factors identified for predicting surgical need while maintaining a sensitivity of 100%.
Article Synopsis
- The study aimed to identify risk factors for immediate neurosurgical intervention in patients with mild traumatic brain injuries and isolated subdural hematomas, using data from 6 trauma centers over a 5-year period.
- Out of 1333 patients, 117 (8.8%) required surgery within 48 hours, with significant predictors being demographic factors like sex and mechanism of injury, as well as radiographic details like hemorrhage thickness and midline shift.
- Ultimately, the combined analysis highlighted that advanced directives, Injury Severity Score, midline shift, and maximum hemorrhage thickness were crucial indicators for determining the need for surgical intervention shortly after hospital admission.
Understanding the intricate ecological interactions within the microbiome of arthropod vectors is crucial for elucidating disease transmission dynamics and developing effective control strategies. In this study, we investigated the ecological roles of Coxiella-like endosymbiont (CLE) and Anaplasma marginale across larval, nymphal, and adult stages of Rhipicephalus microplus. We hypothesized that CLE would show a stable, nested pattern reflecting co-evolution with the tick host, while A.
View Article and Find Full Text PDFExamining the Relation Between Exercise and Word Learning in Preschool-Age Children.
J Speech Lang Hear Res
March 2023
Purpose: There is evidence suggesting that aerobic exercise immediately after vocabulary training can improve word recall in school-age children. This work examined whether the previously identified word-learning benefits associated with exercise can be extended to preschoolers. Additionally, we evaluated whether the effects of physical activity on vocabulary learning may be influenced by existing language skills that the child possesses.
View Article and Find Full Text PDFObjectives: S100A9, an alarmin that can form calprotectin (CP) heterodimers with S100A8, is mainly produced by keratinocytes and innate immune cells. The contribution of keratinocyte-derived S100A9 to psoriasis (Ps) and psoriatic arthritis (PsA) was evaluated using mouse models, and the potential usefulness of S100A9 as a Ps/PsA biomarker was assessed in patient samples.
Methods: Conditional S100A9 mice were crossed with DKO* mice, an established psoriasis-like mouse model based on inducible epidermal deletion of c-Jun and JunB to achieve additional epidermal deletion of S100A9 (TKO* mice).