Publications by authors named "L Mellibovsky"
Article Synopsis
- Scientists found that modern humans have lighter bones than ancient relatives like Neanderthals and that this might be due to both how they lived and genetics.
- They studied a gene called LRP5, which affects bone strength, and discovered it behaves differently in ancient and modern people.
- Their research shows that there are unique genetic changes in modern humans compared to ancient ones, which might help explain why our bones are different today.
Osteoporosis is the most common bone disease, characterized by a low bone mineral density (BMD) and increased risk of fracture. At the other end of the BMD spectrum, some individuals present strong, fracture-resistant, bones. Both osteoporosis and high BMD are heritable and their genetic architecture encompasses polygenic inheritance of common variants and some cases of monogenic highly penetrant variants in causal genes.
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- Chiari malformation type 1 (C1M) is linked to genetic factors associated with bone development, suggesting cranial bone constriction may play a role in its occurrence.
- Researchers conducted a study with 12 C1M patients to explore the relationship between specific bone-related genes and bone mineral density (BMD).
- Variants in multiple bone-related genes were found in certain C1M patients, but no direct correlation was established between BMD and C1M, indicating that further research is needed to understand the genetic influences on this condition.