Publications by authors named "L Mellhammar"
Background: Diagnosing sepsis remains a challenge because of the lack of gold-standard diagnostics. Since there are no simple, broadly accepted criteria for infection, there is a risk of misclassifying sepsis patients (sepsis mimics) among patients with organ failure. The main objective of this study was to investigate the proportion of non-infected patients (sepsis mimics) in ICU patients with presumed sepsis at intensive care unit (ICU) admission.
View Article and Find Full Text PDFIntroduction: Epidemiological data on extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales are most often based on microbiological laboratory isolates and do not consider important clinical data such as infection or colonisation, treatment, and outcome. This study aimed to assess prevalence of ESBL-producing Enterobacterales as the cause of infection in patients with suspected sepsis in the emergency department based on clinical data. It also examined the number of patients with suspected sepsis who had ESBL-producing pathogens, comparing estimates that were based on laboratory data versus a combination of laboratory clinical data.
View Article and Find Full Text PDFBackground: The underlying mechanisms of thrombosis in Lemierre's syndrome and other septic thrombophlebitis are incompletely understood. Therefore, in this case control study we aimed to generate hypotheses on its pathogenesis by studying the plasma proteome in patients with these conditions.
Methods: All patients with Lemierre's syndrome in the Skåne Region, Sweden, were enrolled prospectively during 2017 to 2021 as cases.
Article Synopsis
- The study highlights the lack of reliable data on sepsis epidemiology, emphasizing that existing methods using ICD codes may miss many cases due to low sensitivity and inability to track pathogens or antimicrobial resistance.
- The researchers aimed to improve epidemiological estimates by linking a population-based database with detailed clinical medical record reviews from Sweden.
- Their findings revealed a sepsis incidence of 4.1% among hospitalized patients in 2019, and they noted significant demographic details about the patients, such as age, gender, and comorbidities.
Objectives: The aim of this study was to compare readmissions and death between sepsis and non-sepsis hospitalisations the first year after discharge, and to investigate what diagnoses patients with sepsis present with at readmission. The aim was also to evaluate to what degree patients hospitalised for sepsis seek medical attention prior to hospitalisation.
Design: Retrospective case-control study with data validated through clinical chart review.