Development and publication of new polarographic and related methods of analysis.

A review is made of the factors that should be investigated in the development of new polarographic methods of analysis. Recommendations are made concerning the preparation for publication of the results of such investigations.

Automatic classification of chemical behaviour by sequential hypothesization and multiparametric curve-fitting-III Fully computerized elucidation of polarographic data on stepwise complex formation.

A fully automatic procedure, based on the polarographic technique of DeFord and Hume, is described for deducing the formula of the highest complex formed in the reaction of a metal ion with a ligand and for evaluating the successive overall formation constants. Its results are indistinguishable from those of careful graphical analysis in the traditional fashion.

Automatic classification of chemical behaviour by sequential hypothesization, multiparametric curve-fitting and deviation-pattern recognition-I Fully computerized evaluation of the functionality of a base from titration-curve data.

A completely automatic procedure is described for evaluating the functionality j of a base from the potentiometric titration curve obtained on titration with standard acid. It involves successive hypotheses that j = 1, 2,..

Acid-base titration curves for acids with very small ratios of successive dissociation constants.

The shapes of the potentiometric acid-base titration curves obtained in the neutralizations of polyfunctional acids or bases for which each successive dissociation constant is smaller than the following one are examined. In the region 0 < < 1 (where is the fraction of the equivalent volume of reagent that has been added) the slope of the titration curve decreases as the number j of acidic or basic sites increases. The difference between the pH-values at = 0.

Distinguishing polyfunctional from monofunctional acids and bases by acid-base titrimetry, multiparametric curve-fitting, and deviation-pattern recognition.

A new technique for distinguishing diacidic from monoacidic weak bases (or dibasic from monobasic weak acids) is based on fitting the data obtained in a potentiometric acid-base titration to theoretical equations for the titration of a monoacidic base (or monobasic acid). If the substance titrated is not monofunctional the best fit to these equations will involve systematic deviations that, when plotted against the volume of reagent, yield a "deviation pattern" with a shape characteristic of polyfunctional behaviour. Ancillary criteria based on the values of the parameters obtained from the fit are also described.