Modifiable risk factors for cognitive decline in community-dwelling older adults differ by sex and APOE4.

Objectives: The extent to which lifestyle shapes trajectories of normal cognitive aging, and the factors with highest potential for mitigating cognitive decline, remain poorly uncharacterized.

Method: Participants of the Rancho Bernardo Study underwent demographic, health, and behavioral characterization at baseline, along with up to seven cognitive assessments over a 27-year follow-up period. Factor analysis of 24 baseline risk variables identified 9 composite factors.

The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer's Disease and Related Dementias.

Background: Adult Changes in Thought (ACT), a prospective cohort study, enrolls older adult members of Kaiser Permanente Washington. We describe an ambitious project to abstract medical records facilitating epidemiological investigation.

Methods: Abstracted data include medications; laboratory results; women's health; blood pressure; physical injuries; cardiovascular, neurological, psychiatric and other medical conditions.

Physics-Informed Masked Autoencoder for active sparse imaging.

Imaging technology based on detecting individual photons has seen tremendous progress in recent years, with broad applications in autonomous driving, biomedical imaging, astronomical observation, and more. Comparing with conventional methods, however, it takes much longer time and relies on sparse and noisy photon-counting data to form an image. Here we introduce Physics-Informed Masked Autoencoder (PI-MAE) as a fast and efficient approach for data acquisition and image reconstruction through hardware implementation of the MAE (Masked Autoencoder).

The genetic and environmental etiology of novel frequency-driven regional parcellations of abnormal white matter.

The prevalence of white matter disease increases with age and is associated with cerebrovascular disease, cognitive decline, and risk for dementia. MRI measures of abnormal signal in the white matter (AWM) provide estimates of damage, however, regional patterns of AWM may be differentially influenced by genetic or environmental factors. With our data-driven regional parcellation approach, we created a probability distribution atlas using Vietnam Era Twin Study of Aging (VETSA) data (n = 475, mean age 67.

Association Between Traumatic Brain Injury and Cognitive Decline Among Middle-to-Older Aged Men in the Vietnam Era Twin Study of Aging.

Traumatic brain injury (TBI) is associated with increased risk of dementia. However, whether TBI is associated with greater cognitive decline over time in specific cognitive domains among older adults is not well understood. This prospective cohort study used data from 1476 male Vietnam Era Twin Study of Aging participants (average age at study entry = 57.