Publications by authors named "L Mavarani"
Article Synopsis
- The study investigated whether polygenic scores (PGS) related to Major Depressive Disorder (MDD) and antidepressant treatment response (ADR) can predict how patients respond to antidepressants in a specific trial cohort.
- It included 481 MDD patients undergoing treatment over eight weeks, but while PGS for MDD was linked to higher genetic risk in patients compared to controls, it did not predict treatment outcomes like remission or response.
- The findings suggest a genetic component to MDD, but limitations like treatment variability and sample size indicate that more focused research is necessary to understand the genetic factors influencing antidepressant response.
The risk of preterm birth (PTB) and stillbirth increases after a SARS-CoV-2 infection during gestation. We aimed to estimate the risk depending on gestational age at infection (early <28 + 0 and late ≥28 weeks of gestation, WoG), virus variants, severity of infection, and vaccination. PTB was divided into early PTB (<32 + 0) and late PTB (32 + 0-36 + 6 WoG).
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- Angioedema is a serious reaction linked to ACE inhibitors, and its causes include genetic and non-genetic factors; recent studies have begun to uncover genetic risk factors but not the full underlying mechanisms.!* -
- Researchers analyzed data from over 1,000 European patients, discovering three significant genetic risk loci associated with ACEi-induced angioedema, one of which has not been previously noted.!* -
- The findings underscored the role of bradykinin signaling and coagulation pathways while suggesting new genetic candidates involved in angioedema, highlighting similar genetic effects in both European and African-American patients.!*
Article Synopsis
- Traditional cardiovascular risk scores don't accurately reflect the risk of cardiovascular diseases in people living with HIV (PLH).
- The study analyzed data from the HIV HEART Aging study involving 1,243 PLH over 5 years, using Cox proportional hazards models to identify associations between HIV-specific and traditional cardiovascular risk factors (CRF) and incident CVD.
- Key findings include that a history of AIDS and older age at HIV diagnosis increased CVD risk, while a higher CD4/CD8 ratio and longer antiretroviral therapy duration correlated with decreased risk; traditional CRF, particularly smoking, still significantly affected CVD outcomes.
Different therapeutic apheresis techniques have been clinically tested to delay preterm delivery in the case of eoPE (early-onset preeclampsia). Our study evaluated the feasibility of TPE (therapeutic plasma exchange) compared to standard-of-care treatment. Twenty patients treated with 95 TPE sessions were included in the final analysis and retrospectively matched with 21 patients with comparable placental dysfunction.
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