Publications by authors named "L Maurillo"
Acute myeloid leukemia (AML) with inv(16) is typically associated with a favourable prognosis. However, up to 40 % of patients will eventually experience disease relapse. Herein, we dissected the genomic and transcriptomic profile of inv(16) AML to identify potential prognostic markers and therapeutic vulnerabilities.
View Article and Find Full Text PDFReal-world data on treatment patterns and outcomes of patients with acute myeloid leukemia unfit for intensive chemotherapy are lacking before the advent of precision medicine in this setting. Herein, we present the Italian sub-analysis of the CURRENT study in AML patients unfit for first line intensive chemotherapy, evaluating patients' outcomes between 2015 and 2018. Among 74 evaluable patients, 62 received systemic treatments (most used therapy was hypomethylating agents), while 12 best supportive care.
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- The study aimed to determine the prevalence of latent tuberculosis infection (LTBI) in patients with acute leukemia (AL) using the QuantiFERON (QFT)-TB test, as there's no established screening program for such patients in low TB incidence countries.
- A total of 62 AL patients were screened, with 11.3% testing positive for LTBI, and no patients showing symptoms of active TB during the observation period.
- The findings suggest that LTBI may be more prevalent in Italy than previously thought, highlighting the need for TB screening before starting treatment in AL patients, especially as new treatment options become available.