Publications by authors named "L Masters"
Article Synopsis
- * Early intermittent feeding of mice on a high-cholesterol diet speeds up atherosclerosis by altering arterial macrophage behavior and gene expression associated with ASCVD.
- * The Young Finns Study links early cholesterol exposure to increased carotid atherosclerotic plaque in adulthood, emphasizing the need for better hyperlipidaemia management early in life to prevent ASCVD.
Article Synopsis
- A clinical trial called RADICALS-HD studied the effects of adding short-course androgen deprivation therapy (ADT) to postoperative radiotherapy in patients with localized prostate cancer after surgery.
- It involved 1480 patients, examining how ADT impacts metastasis-free survival compared to radiotherapy alone, and measured outcomes like distant metastasis and overall survival.
- The trial aimed to see if combining ADT with radiotherapy could improve the 10-year metastasis-free survival rate, potentially increasing it from 80% to 86%.
Article Synopsis
- Angiosperms are vital for ecosystems and human life, making it important to understand their evolutionary history to grasp their ecological dominance.
- The study builds an extensive tree of life for about 8,000 angiosperm genera using 353 nuclear genes, significantly increasing the sampling size and refining earlier classifications.
- The findings reveal a complex evolutionary history marked by high gene tree conflict and rapid diversification, particularly during the early angiosperm evolution, with shifts in diversification rates linked to global temperature changes.
This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity of human milk against COVID-19 was found in colostrum from infected mothers. Neutralizing activity was associated with high levels of specific IgA.
View Article and Find Full Text PDFAims: The adaptive immune response plays an important role in atherosclerosis. In response to a high-fat/high-cholesterol (HF/HC) diet, marginal zone B (MZB) cells activate an atheroprotective programme by regulating the differentiation and accumulation of 'poorly differentiated' T follicular helper (Tfh) cells. On the other hand, Tfh cells activate the germinal centre response, which promotes atherosclerosis through the production of class-switched high-affinity antibodies.
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