Publications by authors named "L Mastalerz"
Background: Asthma is associated with a prothrombotic state. Plasma factor VIIa-antithrombin complex concentrations (FVIIa-AT) indirectly reflect the interaction of tissue factor (TF) with FVII. Since TF is a key initiator of coagulation in vivo, we hypothesized that FVIIa-AT are higher in asthma.
View Article and Find Full Text PDFBackground: Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease (NSAIDs-ERD) is characterized by altered arachidonic acid (AA) metabolism. Aspirin hypersensitivity is diagnosed using aspirin challenge, while induced sputum is collected to perform cell counts and to identify local biomarkers in induced sputum supernatant (ISS). This study aimed to assess the levels of a newly identified eicosanoid, 15-oxo-eicosatetraenoic acid (15-oxo-ETE), in ISS at baseline and during aspirin-induced bronchospasm in patients with NSAIDs-ERD.
View Article and Find Full Text PDFArticle Synopsis
- 15-oxo-eicosatetraenoic acid (15-oxo-ETE) is linked to arachidonic acid metabolism and was found to be overproduced in patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD).
- A study involving patients with N-ERD, asthmatics who tolerate aspirin, and healthy controls measured levels of 15-oxo-ETE and leukotriene E (LTE) to evaluate their potential as diagnostic markers.
- Results showed that 15-oxo-ETE levels were significantly higher in N-ERD patients, leading to the development of the Aspirin Hypersensitivity Diagnostic Index (AHDI) which showed strong accuracy in