Publications by authors named "L Maryn Butcher"
Aims: GLP-1 receptor agonists (GLP-1 RAs) are proven therapies for type 2 diabetes mellitus (T2DM) and overweight or obesity. We performed non-clinical and first-in-human (FIH) evaluation of ECC5004/AZD5004, an oral small-molecule GLP-1 RA.
Materials And Methods: ECC5004 was profiled in cell lines overexpressing human GLP-1R, in glucose-stimulated insulin secretion (GSIS) assays in a human β-cell line and non-human primates (NHPs).
Aim: Food literacy programs aim to improve food related skills and knowledge and are selected Governments as a strategy to address dietary intakes at a community level. The purpose of this research is to identify behaviour change techniques in a food literacy program, which were assessed by the achievement of participant goals related to food literacy and dietary behaviour changes.
Methods: Consensus methods were applied to map behaviour change techniques to an adult food literacy program.
Objectives: Unexplained chronic cough (UCC) is common and has significant impacts on quality of life. Ongoing cough can sensitize the larynx, increasing the urge to cough and perpetuating the cycle of chronic cough. Vibrotactile stimulation (VTS) of the larynx is a noninvasive stimulation technique that can modulate laryngeal somatosensory and motor activity.
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- Frailty is common among older adults with diabetes, and higher levels of the biomarker sRAGE may predict mortality; however, the connection between sRAGE and mortality in this population is not fully established.
- A study of 391 older adults with diabetes found that those with higher sRAGE levels had increased mortality, especially among frail individuals.
- The results suggest that frail older adults are more significantly impacted by elevated sRAGE levels, indicating a need for further exploration of frailty in diabetes-related health outcomes.
Objective: To determine the effect of Food Sensations for Adults on food literacy behaviors and selected dietary behaviors.
Methods: A quasi-experimental design using preprogram and postprogram questionnaires over 4 weeks with a control group (n = 75) matched for sex, age group, and socioeconomic disadvantage to program participants (n = 867). General linear mixed models assessed change in food literacy behavior frequency in 3 self-reported domains (plan and manage, selection, and preparation) and fruit and vegetable servings.