Publications by authors named "L Martinez-Pineiro"
Article Synopsis
- Patients with a type of bladder cancer called NMIBC need special treatment after their surgery to help prevent the cancer from coming back, and they usually get a medicine called BCG.
- There have been issues figuring out the best way to use BCG since not everything about how it works is clear, and this has changed how doctors treat the cancer over the years.
- Recently, there have been shortages of BCG, leading doctors to change their treatment plans and look for new ways to help patients feel better and improve their chances against cancer.
The short-lived nature and heterogeneity of Natural Killer (NK) cells limit the development of NK cell-based therapies, despite their proven safety and efficacy against cancer. Here, we describe the biological basis, detailed phenotype and function of long-lived anti-tumour human NK cells (CD56CD16), obtained without cell sorting or feeder cells, after priming of peripheral blood cells with Bacillus Calmette-Guérin (BCG). Further, we demonstrate that survival doses of a cytokine combination, excluding IL18, administered just weekly to BCG-primed NK cells avoids innate lymphocyte exhaustion and leads to specific long-term proliferation of innate cells that exert potent cytotoxic function against a broad range of solid tumours, mainly through NKG2D.
View Article and Find Full Text PDFArticle Synopsis
- The objective of the study was to create performance metrics for a standard transurethral resection of bladder tumors (TURBT) procedure and gain consensus from international experts on these metrics.
- The methodology involved defining the TURBT procedure through detailed phases, steps, and types of errors, followed by evaluation and refinement through a modified Delphi process with a panel of experienced urologists.
- The results showed that the Delphi panel reached a unanimous 100% consensus on the performance metrics, confirming their validity and paving the way for their use in training programs for TURBT.
Introduction: Renal trauma is the most common of urological trauma and accounts for up to 5% of all. The AAST scale is the most widely used to assess renal trauma. This study focuses on high-grade trauma, whose treatment has evolved towards a conservative approach, with techniques such as angioembolization.
View Article and Find Full Text PDFIntroduction: The improved image resolution of IMAGE1 S technology will increase tumor detection, achieve a greater number of complete resections, and would probably have an impact on the reduction of recurrences.
Aim: The primary objective was to compare the recurrence rates of IMAGE1 S vs. white light during transurethral resection of the bladder (TUR); the secondary objective was to compare the complication rates according to Clavien-Dindo (CD) at 12 months of follow-up.