Publications by authors named "L Martinez-Dolz"
Article Synopsis
- The study examines the effectiveness and safety of ultrafiltration (UF) compared to traditional diuretic therapy in treating cardiac decompensation associated with cardiorenal syndrome (CRS), especially when diuretics yield poor results.
- Analyzed data from 13 studies involving around 1,100 patients showed that UF had better trends in reducing creatinine and facilitating greater weight loss and fluid removal compared to diuretics, without impacting mortality or hospital stay durations significantly.
- The findings suggest that UF could be a beneficial alternative for patients not responding well to diuretics, potentially lowering readmission rates, though further prospective studies are necessary to confirm these benefits.
Article Synopsis
- Complications from community-acquired pneumonia (CAP), such as cardiovascular events and mortality, can arise both during the illness and afterward; this study explores the role of specific biomarkers related to endothelial damage compared to traditional inflammation markers.
- The research analyzed data from 515 patients, measuring various biomarkers at different time intervals (day 1, day 5, and day 30) to determine their relationship with ICU admission, cardiovascular events, and mortality.
- Findings indicated that endothelial damage biomarkers (CT-proET-1 and MR-proADM) were more strongly associated with negative outcomes than inflammation markers (CRP and PCT), with MR-proADM being the most effective at predicting complications in both the short and long term.
Introduction And Objectives: In patients with established chronic coronary syndrome (CCS), the significance of persistent angina is controversial. We aimed to evaluate the prognostic role of persistent angina in symptomatic CCS patients with abnormal stress cardiovascular magnetic resonance (CMR) and altered angiographic findings undergoing percutaneous revascularization.
Methods: We analyzed 334 CCS patients with Canadian Cardiovascular Society angina class ≥2, perfusion deficits on stress CMR and severe lesions in angiography who underwent medical therapy optimization plus CMR-guided percutaneous revascularization.
Comparative Temporal Analysis of Morbidity and Early Mortality in Heart Transplantation with Extracorporeal Membrane Oxygenation Support: Exploring Trends over Time.
Biomedicines
September 2024
Article Synopsis
- - The study investigates the impacts of using venoarterial extracorporeal membrane oxygenation (VA-ECMO) as a support mechanism for patients undergoing urgent heart transplants over a 17-year period, focusing on morbidity and mortality rates.
- - Results indicate that while the number of patients able to receive transplants without mechanical ventilation has increased, there have been no significant changes in overall mortality rates within 30 days, one year, or five years across different time periods.
- - Comorbidity rates were high, averaging 3.33 per patient, with common complications including vascular issues, the need for post-transplant ECMO, and myopathy, especially more pronounced in recent years.
Following myocardial infarction (MI), adverse remodeling depends on the proper formation of fibrotic scars, composed of type I and III collagen. Our objective was to pinpoint the participation of previously unreported collagens in post-infarction cardiac fibrosis. Gene (qRT-PCR) and protein (immunohistochemistry followed by morphometric analysis) expression of fibrillar (types II and XI) and non-fibrillar (types VIII and XII) collagens were determined in RNA-sequencing data from 92 mice undergoing myocardial ischemia; mice submitted to permanent (non-reperfused MI, n = 8) or transient (reperfused MI, n = 8) coronary occlusion; and eight autopsies from chronic MI patients.
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