Publications by authors named "L Marins"
Deep learning has proven capable of automating key aspects of histopathologic analysis. However, its context-specific nature and continued reliance on large expert-annotated training datasets hinders the development of a critical mass of applications to garner widespread adoption in clinical/research workflows. Here, we present an online collaborative platform that streamlines tissue image annotation to promote the development and sharing of custom computer vision models for PHenotyping And Regional Analysis Of Histology (PHARAOH; https://www.
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- Infectious myonecrosis virus (IMNV) leads to considerable economic and social challenges in shrimp farming in the U.S. and Asia.
- This study focused on the transcriptional changes of key RNAi mechanism genes (Sid-1, Dicer-2, Argonaute-2) in Penaeus vannamei infected with varying concentrations of IMNV.
- Results showed that higher IMNV concentrations impacted transcription levels of these genes, but the overall viral load remained unchanged, suggesting Sid-1 mRNA expression as a potential marker for monitoring viral replication in shrimp farming.
Article Synopsis
- A genomic database encompassing all eukaryotic species on Earth is crucial for scientific advancements, yet most species lack genomic data.
- The Earth BioGenome Project (EBP) was initiated in 2018 by global scientists to compile high-quality reference genomes for approximately 1.5 million recognized eukaryotic species.
- The European Reference Genome Atlas (ERGA) launched a Pilot Project to create a decentralized model for reference genome production by testing it on 98 species, providing valuable insights into scalability, equity, and inclusiveness for genomic projects.
Article Synopsis
- The study investigated therapeutic targets linked to Cancer Stem Cell changes in recurrent patients with Testicular Germ Cell Tumor (TGCT) and Uterine Corpus Endometrial Carcinoma (UCEC) using data from TCGA.
- Researchers found that specific cancer stem cell transcription factors showed high expression levels in both cancer types, correlating with poorer patient outcomes when certain genes were altered.
- The analysis suggested that the kinases PIM1 and PRKACA might influence the phosphorylation of the gene POU5F1, particularly in relation to recurrent cases.