Publications by authors named "L Marije Hofstra"
Background: Left ventricular ejection fraction (EF) is used to categorize heart failure (HF) into phenotypes but this information is often missing in electronic health records or non-HF registries.
Methods: We tested the applicability of a simplified version of a multivariable algorithm, that was developed on data of the Swedish Heart Failure Registry to predict EF in patients with HF. We used data from 4,868 patients with HF from the Cardiology Centers of the Netherlands database, an organization of 13 cardiac outpatient clinics that operate between the general practitioner and the hospital cardiologist.
Background: The World Health Organization (WHO) recommends that HIV treatment scale-up is accompanied by a robust assessment of drug resistance emergence and transmission. The WHO HIV Drug Resistance (HIVDR) monitoring and surveillance strategy includes HIVDR testing in adults both initiating and receiving antiretroviral therapy (ART). Due to limited information about HIVDR in Mozambique, we conducted two nationally representative surveys of adults initiating and receiving first-line ART regimes to better inform the HIV program.
View Article and Find Full Text PDFCirculating proteins may provide insights into the varying biological mechanisms involved in heart failure (HF) with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). We aimed to identify specific proteomic patterns for HF, by comparing proteomic profiles across the ejection fraction spectrum. We investigated 4210 circulating proteins in 739 patients with normal (Stage A/Healthy) or elevated (Stage B) filling pressures, HFpEF, or ischemic HFrEF (iHFrEF).
View Article and Find Full Text PDFArticle Synopsis
- HIV persists in the central nervous system (CNS) of people living with HIV, leading to cognitive impairments even with antiretroviral therapy (ART).
- Researchers analyzed paired cerebrospinal fluid (CSF) and blood samples from 19 untreated adults, finding higher HIV RNA levels in plasma compared to CSF and mostly consistent coreceptor usage.
- The study revealed that some viruses in the CNS can replicate in microglia (brain immune cells) as well as T-cells, suggesting that viral evolution may help the infection spread within the CNS, which needs further investigation.
Article Synopsis
- The study examines how kidney dysfunction correlates with left ventricular diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF), focusing on whether these associations differ between sexes.
- Data was collected from 880 participants, revealing that those with mild to moderate kidney dysfunction had significantly higher rates of HFpEF compared to those with normal kidney function, along with elevated measures of heart function.
- The findings suggest that both mild and moderate kidney dysfunction are major risk factors for HFpEF, with the strongest link found in moderate dysfunction, indicating the need for early intervention in at-risk groups.