Publications by authors named "L Marchioni"
Article Synopsis
- COVID-19 has been linked to increased cases of pneumothorax (PTX) and pneumomediastinum (PNM), leading to concerns about poor patient outcomes and factors affecting mortality.
- This observational study, analyzing data from nearly 12,000 COVID-19 patients in central Italy, identified specific risk factors for 28-day mortality and need for intubation related to pulmonary barotrauma.
- Key risk factors for higher mortality included elevated SOFA scores, use of vasopressors, hypercapnia, low PaO/FiO ratio, and existing cardiovascular disease, while variants of concern did not impact mortality rates.
Article Synopsis
- COVID-19 can lead to acute respiratory distress syndrome, requiring ICU admission and invasive ventilation, which increases the risk of ventilator-associated pneumonia (VAP) in these patients.
- A study of 284 ICU patients with COVID-19 found a 33% incidence of VAP, predominantly caused by Pseudomonas aeruginosa and Klebsiella spp., with significant antimicrobial resistance noted in these bacteria.
- Key risk factors for developing VAP included receiving blood transfusions and certain therapies, with higher VAP rates linked to orotracheal intubation compared to tracheostomy, although patient positioning and specific admission ratios did not correlate significantly with VAP incidence.
Despite the higher transmissibility of Omicron Variant of Concern (VOC), several reports have suggested lower risk for hospitalization and severe outcomes compared to previous variants of SARS-CoV-2. This study, enrolling all COVID-19 adults admitted to a reference hospital who underwent both the S-gene-target-failure test and VOC identification by Sanger sequencing, aimed to describe the evolving prevalence of Delta and Omicron variants and to compare the main in-hospital outcomes of severity, during a trimester (December 2021 to March 2022) of VOCs' cocirculation. Factors associated with clinical progression to noninvasive ventilation (NIV)/mechanical ventilation (MV)/death within 10 days and to MV/admission to intensive care unit (ICU)/death within 28 days, were investigated through multivariable logistic regressions.
View Article and Find Full Text PDF: In Italy, by the end of 2021, a new pandemic wave led to increased hospitalizations and death, even in some vaccinated people. We aimed to investigate the death of COVID-19-vaccinated patients who acquired infection and developed severe disease, and to assess differences with fatal COVID-19 in unvaccinated subjects by studying the pathological events triggered by SARS-CoV-2. : Detailed autoptic examination was performed on five fully vaccinated compared to five unvaccinated patients.
View Article and Find Full Text PDFSelf-diffusion D in a system of particles that interact with a pseudo-hard-sphere or a Lennard-Jones potential is analyzed. Coupling with a solvent is represented by a Langevin thermostat, characterized by the damping time t_{d}. The hypotheses that D=D_{0}φ is proposed, where D_{0} is the small concentration diffusivity and φ is a thermodynamic function that represents the effects of interactions as concentration is increased.
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