Publications by authors named "L Manfredi"
Article Synopsis
- The shift from a comorbidity-focused approach to a multimorbidity perspective in managing rheumatic diseases emphasizes the presence of multiple diseases, resulting in greater individual and societal impacts, but often leads to fragmented care.
- Network medicine presents a more integrated approach by examining the interactions and connections between different diseases at a biological level, focusing on shared pathways and mechanisms.
- This paradigm shift allows for a holistic understanding of rheumatic diseases, highlighting their interconnectedness through systemic inflammation and immune system dysregulation.
Article Synopsis
- A study analyzed the link between different levels of food processing and the risk of developing type 2 diabetes, using data from the EPIC cohort involving nearly 312,000 participants over about 11 years.
- The results showed that higher intake of ultra-processed foods (UPF) was significantly associated with an increased risk of type 2 diabetes, while unprocessed/minimally processed foods and processed foods were linked to a lower risk.
- Sub-group analysis revealed specific types of UPF, like certain breads and plant-based alternatives, that, surprisingly, were associated with a reduced risk of developing type 2 diabetes.
Article Synopsis
- Inflammatory bowel disease (IBD) includes conditions like Crohn's disease and ulcerative colitis, leading to chronic inflammation in the digestive tract, with increasing prevalence worldwide, especially in developing regions.
- Optical colonoscopy is a key diagnostic tool for IBD, enabling real-time visualization and tissue sampling, but its effectiveness relies heavily on the skills of the endoscopist.
- The use of deep learning algorithms to improve colonoscopy image analysis for IBD detection is still emerging, highlighting the need for more annotated datasets to enhance AI-driven diagnosis and management of the disease.
Objectives: Our study aimed to investigate how physical activity (PA) changes over an 11-year follow-up among adults from different socioeconomic positions (SEP) near retirement age. Moreover, an analysis of different PA types is considered.
Methods: We used data from the EPIC-Italy cohort.