Publications by authors named "L Mancinelli"
Cardiovascular diseases (CVDs) persist as the primary cause of death worldwide, accounting for roughly 17.9 million fatalities each year. The prevalence of obesity, metabolic syndrome, and type 2 diabetes (key risk factors for CVD) continues to escalate at an alarming rate, necessitating novel therapeutic strategies to address this global health crisis.
View Article and Find Full Text PDFBackground: Hypogammaglobulinemia (HG) is a known side effect of treatment with anti-CD20 monoclonal antibodies, and it is associated with the risk of infections.
Objectives: Aim of this retrospective multicentre study was to assess the frequency of HG in Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorder patients treated with Ocrelizumab or Rituximab and its association with the occurrence of severe infections (SI). Furthermore, predictors of HG and SI were sought.
Article Synopsis
- The study focused on the relationship between Torquetenovirus (TTV) levels, inflammation markers, and the risk of Ischemic Heart Disease (IHD) in older adults, revealing limited research on this topic.
- Findings from 900 non-IHD participants and 86 IHD individuals indicated that elevated TTV viremia was a significant predictor of IHD risk, particularly in males and in conjunction with other health factors like diabetes and smoking.
- The research suggests that high TTV levels are linked to increased inflammation and may contribute to IHD risk through mechanisms related to aging and immune response deterioration.
Background: FNDs mimicking a stroke represent a growing challenge in the emergency department (ED). A comprehensive diagnostic approach involving clinical evaluation and neuroimaging is essential to differentiate stroke from mimics. The safety profile of thrombolysis justifies its use where FNDs cannot be ruled out.
View Article and Find Full Text PDFBackground: Cardiac involvement following an acute stroke (Stroke Heart Syndrome-SHS) is an established complication and it is linked to the involvement of sympathetic activation, inflammation, and neuro-endocrine response. Troponin "rise and fall pattern" > 30% is one marker of SHS. The aim of this study was to evaluate the role of reperfusion treatments in the prevention/pathogenesis of SHS with different stroke sizes and locations (OCSP classification).
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