Publications by authors named "L Mamanova"
Positional coding along the anterior-posterior axis is regulated by HOX genes, whose 3' to 5' expression correlates with location along this axis. The precise utilisation of HOX genes in different human cell types is not fully understood. Here, we use single-cell and spatial-transcriptomics, along with in-situ sequencing, to create a developmental atlas of the human fetal spine.
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- The study investigates early cellular responses to SARS-CoV-2 infection using single-cell profiling in individuals with no prior immunity to the virus.
- Significant changes in cell types and immune responses were observed over time, indicating different patterns of infection severity, especially in nasopharyngeal regions.
- Key findings suggest that early interferon responses and specific immune cell behaviors, like high expression of HLA-DQA2, could be crucial in preventing sustained infections, while a novel computational tool, Cell2TCR, enhanced the analysis of T cell responses.
Children infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk of mortality in infected people over 85 years of age remains high. Here we investigate differences in the cellular landscape and function of paediatric (<12 years), adult (30-50 years) and older adult (>70 years) ex vivo cultured nasal epithelial cells in response to infection with SARS-CoV-2.
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