Publications by authors named "L Malave"
Introduction: Accurate identification of patients with pathologic complete response (pCR) following neoadjuvant radiochemotherapy (RCT) for locally advanced rectal cancer (LARC) is essential. 18-FDG PET/MRI provides metabolic information that complements the morphological assessment of standard MRI, potentially enhancing the differentiation between fibrotic and tumorous tissues post-treatment. This study aims to evaluate the performance of 18-FDG PET/MRI in assessing treatment response compared to standard MRI.
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- Early Life Adversity (ELA) can lead to increased stress sensitivity in adulthood, particularly affecting females, but the neurobiological mechanisms behind this are not well understood.
- In a study using mice, ELA was shown to decrease serotonin neuron activity and increase stress-related behaviors and hormone levels, while also reducing neurogenesis and increasing inflammation in specific brain regions.
- Targeting serotonin 1A autoreceptors during development appears to prevent the negative impacts of ELA on stress responses and brain function in adult female mice, suggesting potential avenues for intervention.
Background: Striatal Cholinergic Interneurons (CIN) are drivers of L-Dopa induced Dyskinesias (LID). However, what signaling pathways elicit aberrant CIN activity remains unclear. CIN express D2 and D5 receptors suggesting repeated activation of these receptors in response to L-Dopa could promote LID.
View Article and Find Full Text PDFEarly Life Adversity (ELA) predisposes to stress hypersensitivity in adulthood, but neurobiological mechanisms that protect from the enduring effects of ELA are poorly understood. Serotonin 1A (5HT ) autoreceptors in the raphé nuclei regulate adult stress vulnerability, but whether 5HT could be targeted to prevent ELA effects on susceptibility to future stressors is unknown. Here, we exposed mice with postnatal knockdown of 5HT autoreceptors to the limited bedding and nesting model of ELA from postnatal day (P)3-10 and tested behavioral, neuroendocrine, neurogenic, and neuroinflammatory responses to an acute swim stress in male and female mice in adolescence (P35) and in adulthood (P56).
View Article and Find Full Text PDFBackground: The watch-and-wait (WW) strategy is a potential option for patients with rectal cancer who obtain a complete clinic response after neoadjuvant therapy. The aim of this study is to analyze the long-term oncological outcomes and perform a cost-effectiveness analysis in patients undergoing this strategy for rectal cancer.
Material And Methods: The data of patients treated with the WW strategy were prospectively collected from January 2015 to January 2020.