Publications by authors named "L Magnelli"
The complex and continuously evolving features of the tumor microenvironment, varying between tumor histotypes, are characterized by the presence of host cells and tumor cells embedded in a milieu shaped by hypoxia and low pH, resulting from the frequent imbalance between vascularity and tumor cell proliferation. These microenvironmental metabolic stressors play a crucial role in remodeling host cells and tumor cells, contributing to the stimulation of cancer cell heterogeneity, clonal evolution, and multidrug resistance, ultimately leading to progression and metastasis. The extracellular vesicles (EVs), membrane-enclosed structures released into the extracellular milieu by tumor/host cells, are now recognized as critical drivers in the complex intercellular communication between tumor cells and the local cellular components in a hypoxic/acidic microenvironment.
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- The study explores the use of Human Amniotic Membrane (hAM) as a potential treatment for various eye conditions, showing promising effects on retinal health, particularly for issues like macular holes and retinal detachments.
- Researchers developed a hAM extract (hAME) using a non-denaturing sonication technique and tested it on ARPE-19 cells, discovering that hAME enhances cell viability under stress and prevents harmful changes associated with epithelial-mesenchymal transition (EMT).
- The findings indicate that hAME retains beneficial properties of hAM tissue and could serve as a cost-effective treatment option for retinal diseases in the future.
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- The study investigates the roles of two enzymes, IDO1 and TDO, in breaking down tryptophan into kynurenine, focusing on their impact on angiogenesis in human endothelial cells.* -
- Using various methods like qRT-PCR and ELISA assays, the research shows that TDO is crucial for the proliferation and tube formation of HUVECs in response to VEGF-A, while IDO1 did not have a significant effect.* -
- The findings suggest that TDO plays a significant role in endothelial cell function and could be important in angiogenesis, indicating a broader role than just immune regulation.*
Gastric cancer (GC) is the fifth most frequent malignancy and the fourth leading cause of worldwide cancer-related death. Despite the usage of multimodal perioperative chemotherapy (pCT), GC progressively gains chemoresistance, thereby, the identification of suitable targets to overcome drug resistance is fundamental. Amongst the potential biomarkers, carbonic anhydrase IX (CAIX) - associated with a poor prognosis of several solid cancers - has gained the most attention.
View Article and Find Full Text PDFBlood vessels are the most important way for cancer cells to survive and diffuse in the body, metastasizing distant organs. During the process of tumor expansion, the neoplastic mass progressively induces modifications in the microenvironment due to its uncontrolled growth, generating a hypoxic and low pH milieu with high fluid pressure and low nutrients concentration. In such a particular condition, reactive oxygen species play a fundamental role, enhancing tumor proliferation and migration, inducing a glycolytic phenotype and promoting angiogenesis.
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