Publications by authors named "L Maggino"
Objective: Ampullary neoplastic lesions can be resected by endoscopic papillectomy (EP) or transduodenal surgical ampullectomy (TSA) while pancreaticoduodenectomy is reserved for more advanced lesions. We present the largest retrospective comparative study analysing EP and TSA.
Design: Of all patients in the database, lesions with prior interventions, benign histology advanced malignancy (T2 and more), patients with hereditary syndromes and those undergoing pancreatoduodenectomy were excluded.
Occult metastases are detected in 10-15% of patients during exploratory laparotomy for pancreatic cancer. This study developed and externally validated a model to predict occult metastases in patients with potentially resectable pancreatic cancer. Model development was performed within the Dutch Pancreatic Cancer Audit, including all patients operated for pancreatic cancer (January 2013-December 2017).
View Article and Find Full Text PDFSignet-ring cell (SRC)/poorly cohesive cell carcinoma is an aggressive variant of pancreatic ductal adenocarcinoma (PDAC). This study aimed to clarify its clinicopathologic and molecular profiles based on a multi-institutional cohort of 20 cases. The molecular profiles were investigated using DNA and RNA sequencing.
View Article and Find Full Text PDF[This corrects the article DOI: 10.3389/fnut.2023.
View Article and Find Full Text PDFArticle Synopsis
- This study explores the significance of pathological staging in predicting outcomes for pancreatic cancer patients after surgery and neoadjuvant therapy.
- It involves 389 patients from two Italian centers and demonstrates that a modified staging system performs better in predicting survival compared to standard methods.
- The findings suggest that certain patients, particularly those with specific tumor characteristics, may benefit from adjuvant therapy, despite no overall survival difference observed in the entire cohort.