Results of an Online Survey on Intensive Care Management of Patients with Aneurysmal Subarachnoid Hemorrhage in German-Speaking Countries.

The clinical course of patients with aneurysmal SAH (aSAH) is often dynamic and highly unpredictable. Since its management varies between hospitals despite guidelines, this survey aimed to assess the current state of intensive care treatment for aSAH in the German-speaking region and provide insights that could aid standardization of care for aSAH patients in the intensive care setting. From February 2023 to April 2023, medical professionals of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI), the Initiative of German Neuro-Intensive Trial Engagement (IGNITE) network and manually recorded clinics with intensive care units were invited to participate in a standardized anonymous online questionnaire including 44 questions.

Insurance, legal, and financial hardships of childhood and adolescent cancer survivors-a systematic review.

Purpose: Childhood and adolescent cancer survivors (CACS) experience medical and psychosocial adverse effects. Attention widens to include issues such as socio-bureaucratic hardships. This systematic review synthesized the available evidence on insurance, legal, and financial hardships to better understand the broader picture of socio-bureaucratic hardships as distinct but interrelated types of hardships.

A practical guide for the assay-dependent characterisation of irreversible inhibitors.

Irreversible targeted covalent inhibitors, in the past regarded as inappropriately reactive and toxic, have seen a recent resurgence in clinical interest. This paradigm shift is attributed to the exploitation of the two-step mechanism, in which a high affinity and selectivity (, low ) scaffold binds the target and only then does a pendant low intrinsic reactivity warhead react with the target (moderate ). This highlights the importance of evaluating inhibitors by deriving both their and values.

Reliability of sEMG data of back muscles during static submaximal loading situations - Values and pitfalls.

Alterations of trunk muscle activity can be objectified using surface electromyography (sEMG). But for diagnostic purposes reliable reference values are needed. Therefore, the present study evaluated sEMG measurements of representative back muscles concerning their reliability.

Psychological distress in adults after pediatric kidney replacement therapy.

Background: There is limited information about psychological distress in adults who underwent kidney replacement therapy (KRT) during childhood. This study aimed to describe psychological distress in adults after KRT during childhood in comparison to the Swiss general population and to evaluate associations with sociodemographic and clinical characteristics.

Methods: We sent a questionnaire to 143 people from the Swiss Pediatric Renal Registry (SPRR), who were alive, over 18 years old, started KRT before the age of 18 years, and were German speakers.