Publications by authors named "L MOSCA"
Topical application of the glucocorticoid betamethasone (BM) is a common treatment for inflammatory-related skin diseases, such as psoriasis. However, enhancing its bioavailability remains challenging due to poor skin permeability. Herein, we developed and evaluated hyaluronan-cholesterol (HACH) based nanohydrogel systems (NHs) and NHs-Carbopol formulation for dermal delivery of BM.
View Article and Find Full Text PDFPurpose: To compare clinical and topographical outcomes of three different surgical strategies for advanced pellucid marginal degeneration (PMD).
Methods: Retrospective, interventional case series of 8 advanced PMDs undergoing three different surgical interventions: Sliding Keratoplasty (SK), Sliding Keratoplasty with Relaxing Incision (SKRI), Sector Lamellar Keratoplasty (SLK). Pre-operatively and at 1, 3, 6, 12-month and final follow-up (50.
Article Synopsis
- * Traditional methods of extracting these compounds are difficult and harmful to the environment, leading to the development of a new aqueous extraction method that transforms them into water-soluble derivatives called thiocanthal and thiocanthol.
- * Thiocanthal and thiocanthol have been shown to have an anti-inflammatory effect greater than ibuprofen and may offer a new avenue for creating safer non-steroidal anti-inflammatory drugs (NSAIDs).
Article Synopsis
- Drug-induced liver injury (DILI), particularly from acetaminophen (APAP) overdose, is a major factor in acute liver failure and liver transplants in the Western world.
- Research shows that neddylation, a modification important for mitochondrial function, is increased in liver samples from APAP injury patients and mice with APAP overdose.
- The inhibitor MLN4924 reduces liver cell damage and enhances regeneration in APAP injury, and the study identifies crucial elements in this process, suggesting new avenues for targeted DILI treatments.
Persistent organic pollutants (POPs), which encompass pesticides and industrial chemicals widely utilized across the globe, pose a covert threat to human health. β-hexachlorocyclohexane (β-HCH) is an organochlorine pesticide with striking stability, still illegally dumped in many countries, and recognized as responsible for several pathogenetic mechanisms. This study represents a pioneering exploration into the neurotoxic effects induced by the exposure to β-HCH specifically targeting neuronal cells (N2a), microglia (BV-2), and C57BL/6 mice.
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