Publications by authors named "L M del Razo"
To determine if fluoride's established negative impact on adult kidney health begins during gestation, an intergenerational model of Wistar rats was exposed to two doses of fluoride (2.5 or 5.0 mg/kg/day via gavage) 20 days before mating and during gestation (20 days).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the combined toxicity of arsenic (As) and fluoride (F) in drinking water, focusing on their effects on the liver of offspring from exposed pregnant mice.
- Results revealed that exposure to As and F significantly disrupted liver function, reducing levels of glutathione (GSH) and indicating increased oxidative stress and potential liver damage at early postnatal days.
- While some recovery of GSH levels was noted with age, persistent issues such as reduced mitochondrial function and fibrotic liver damage highlight ongoing risks from exposure to these substances during critical developmental periods.
Background: DNA damage caused by exposure to metal mixtures and the potential modulating role of genes involved in DNA repair and the antioxidant response have not been evaluated in newborns.
Aim: The aim was to evaluate the association between prenatal exposure to metal mixtures and DNA repair capacity (DRC) in newborns from the Metropolitan Area of Mexico City (MAMC), a heavily polluted area, and the impact of variants in genes involved in DNA repair and the antioxidant response on this association.
Methods: We analyzed cord blood samples obtained at delivery from 125 healthy newborns from the MAMC.
Even though smoking has been scarcely studied in osteoarthritis (OA) etiology, it is considered a controversial risk factor for the disease. Exposure to tobacco smoke has been reported to promote oxidative stress (OS) as part of the damage mechanism. The aim of this study was to assess whether smoking increases cartilage damage through the generation of OS.
View Article and Find Full Text PDFInorganic fluoride is a geogenic and anthropogenic contaminant widely distributed in the environment and commonly identified in contaminated groundwater. There is limited information on the effect of fluoride exposure on pregnancy. The aim of this study was to evaluate possible placental alterations of fluoride exposure in a rat model simulating preconception and pregnancy exposure conditions in endemic areas.
View Article and Find Full Text PDF