Computational Applications: Beauvericin from a Mycotoxin into a Humanized Drug.

Drug discovery was initially attributed to coincidence or experimental research. Historically, the traditional approaches were complex, lengthy, and expensive, entailing costly random screening of synthesized compounds or natural products coupled with in vivo validation largely depending on the availability of appropriate animal models. Currently, in silico modeling has become a vital tool for drug discovery and repurposing.

Isolation and identification of free-living amoebae from some water sources in Alexandria.

Samples from different water sources of Alexandria, and from nasal passages of 500 healthy children inhabiting areas nearby these sources were examined for the presence of free-living amoebae. These samples were cultured on 1.5% non nutrient agar streaked with bacteria.

Aminosidine sulphate in experimental cryptosporidiosis.

The present study aimed at investigating the efficiency of a recent antibiotic Aminosidine sulphate (Gabbroral) in experimental cryptosporidiosis. The course of infection was studied when the drug was given early before the infection, and late during the infection both parasitologically and histopathologically. When the drug was given early, the results were satisfactory, with a significant reduction of size, number and pathological changes of the parasites in the stool and in ileal sections of infected mice.

Studies on T. spiralis and T pseudospiralis larvae recovered from mice immunized with heterologous Trichinella antigen.

In this study, S3 antigen of T. spiralis and T. pseudospiralis was given to the heterologous infection in albino mice.

Cyclosporin A in experimental trichinosis scanning electron microscopic study.

The surface morphology of adult and larvae of Trichinella spiralis after cyclosporin A treatment was studied by scanning electron microscopy (SEM) of fixed, dried and metal coated specimens. The earliest topographic changes revealed in adults after the drug treatment were in form of disorganization of the cuticle especially between the hypodermal pores which appeared somewhat thickened and irregular. Other changes were in form of bullae formation covering the whole width of the adult surface.