Publications by authors named "L M Vincenti"
Background: Level of lymph nodes dissection (LND) and inferior mesenteric artery (IMA) ligation is still matter of debate of radical resection of colorectal cancer. This study aims to compare the short-term outcome of three different surgical techniques to treat sigmoid cancer: low ligation (LL) of the IMA with D3-LND, low IMA ligation with D2-LND, and high ligation (HL) of the IMA with D3-LND.
Methods: Patients affected by sigmoid colon cancer, who underwent radical resection with three different techniques (LL and D3-LND Group A, HL and D3-LND Group B, and LL with D2 LND- Group C), were included.
Background: Diverting ileostomy is a common procedure in rectal cancer surgery, but it is sometimes associated with a nonnegligible rate of complications. The primary aim of this study was to analyze the incidence and types of stoma-related complications for ileostomy creation after rectal cancer resection. The secondary aims were to report the indications, the technical details, and the efficacy of stoma care provided by ostomy nurses.
View Article and Find Full Text PDFNanotechnology advancements have facilitated the development of eco-friendly strategies to combat bacterial infections caused by antibiotic-resistant pathogens. This study promotes a green method for the synthesis of silver nanoparticles (AgNPs) utilizing Eucalyptus globulus leaf extracts as an alternative to traditional colloidal AgNPs obtained through chemical synthesis, investigating their antibacterial efficacy against Pseudomonas aeruginosa and their impact on the expression of bacterial virulence factors (pyocyanin, pyoverdine, rhamnolipids). This work demonstrates that: i.
View Article and Find Full Text PDFArticle Synopsis
- - Periodontitis is linked to a higher risk of colorectal cancer (CRC) and can worsen the prognosis due to increased inflammation and harmful agents from periodontal pathogens.
- - A study evaluated the prevalence and severity of periodontitis among CRC patients, finding it present in over 94% of those with stage I/II and 100% in stages III/IV, with severe periodontitis more common in advanced stages.
- - The findings indicate a significant association between severe periodontitis and CRC but no correlation with patients' general or tumor characteristics and drug therapies.
Article Synopsis
- Cancer-associated fibroblasts (CAFs) contribute to the aggressive nature and treatment resistance of intrahepatic Cholangiocarcinoma (iCCA), prompting research into the effects of the Notch1 inhibitor Crenigacestat on this interaction.
- Using both 2D and 3D in vitro models, along with a xenograft setup, the study found that CAFs enhance iCCA cell migration and growth, but Crenigacestat effectively inhibits this cross-talk and reduces tumor growth and fibrosis.
- Overall, targeting the hCAF/iCCA interaction with Crenigacestat presents a promising approach to slowing cancer progression and altering critical cell cycle pathways.