Characterization of CD4 T Cell Subsets in Patients with Abdominal Aortic Aneurysms.

Background: The mediators produced by CD4 T lymphocytes are involved in the pathogenesis of aneurysmal lesions in abdominal aortic aneurysm (AAA) patients. The aim of this study was to identify and characterize the CD4 T cell subsets involved in human AAA.

Methods: The CD4 T cell subsets in 30 human aneurysmal lesions were determined using flow cytometry (FC) and immunohistochemistry (IHC).

Monocytes of patients with unstable angina express high levels of chemokine and pattern-recognition receptors.

Background And Aims: Macrophages derived from monocytes play an important role in atherosclerosis progression. Subpopulations of circulating classical, intermediate, and non-classical monocytes possess distinct functions and phenotypes, and participate in the pathogenesis of disease. The aim of this study was to compare the quantity and phenotypes of circulating monocyte subpopulations in patients with established atherosclerosis and healthy control individuals.