Association of 30-s Sit-to-Stand Power Test Outcome With Body Balance in Physically Active Older Adults.

Amount of serial sitting and standing movements has been employed in clinical and research settings to assess legs' muscular strength. In this cross-sectional study, we aimed to test the correlation between the 30-s sit-to-stand power test (30STSp) outcome and body balance in older adults. We evaluated physically active male and female (n = 51) individuals with an age range of 60-80 years (M = 69.

DPYD genotype should be extended to rare variants: report on two cases of phenotype / genotype discrepancy.

The enzyme dihydropyrimidine dehydrogenase (DPD) is the primary catabolic pathway of fluoropyrimidines including 5 fluorouracil (5FU) and capecitabine. Cases of lethal toxicity have been reported in cancer patients with complete DPD deficiency receiving standard dose of 5FU or capecitabine. DPD is encoded by the pharmacogene DPYD in which more than 200 variants have been identified.

Implementation of an Oncogeriatric Unit for Frail Older Patients with Breast Cancer: Preliminary Results.

(1) Background: Breast cancer (BC) has a high incidence in Europe, particularly in older adults. Traditionally under-represented in clinical trials, this age group is often undertreated due to ageism. This study aims to characterize frail older adults (≥70 years) with BC based on a comprehensive geriatric assessment, to guide individualized treatment decision-making.

The Sdp-SH3b2 domain contained in N6.2-derived extracellular vesicles inhibit murine norovirus replication.

The internalization of N6.2 extracellular vesicles (EVs) by cells results in a significant induction of the 2',5'-oligoadenylate synthetase (OAS) pathway. It also induces expression of and .

Update on Conventional Osteosarcoma.

Conventional osteosarcoma is a high-grade malignant tumor characterized by the production of osteoid matrix by malignant osteoblasts. It typically affects the long bones of children and adolescents. Treatment includes systemic chemotherapy and a local surgical approach with wide resection.