Publications by authors named "L M T Canzoniero"
Nanoparticles encapsulating phosphatidylinositol derivatives promote neuroprotection and functional improvement in preclinical models of ALS via a long-lasting activation of TRPML1 lysosomal channel.
Pharmacol Res
December 2024
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a progressive and currently incurable neurodegenerative disease characterized by the loss of motor neurons, muscle atrophy, and cellular dysfunction related to protein aggregation and calcium imbalances.
- Researchers have identified autophagy dysfunction as a key area for potential ALS treatment, with TRPML1 being a crucial lysosomal channel that, when properly stimulated, can aid in this process.
- A new lipid-based formulation of PI(3,5)P was developed to effectively stabilize TRPML1 activity in ALS models, showing promising results in improving neuromuscular function, reducing motor neuron loss, and extending the lifespan of SOD1 ALS mice by about 10 days.
Article Synopsis
- - The study explored how the transcription factors Nkx2-1 and Pax8 influence thyroid development and brain functions by examining mice with genetic mutations affecting these factors, focusing on brain abnormalities linked to thyroid conditions.
- - DHTP mice, which have both systemic and brain hypothyroidism, displayed altered neurotransmitter systems, reduced expression of synaptic and glutamate receptor proteins, and imbalances in mitochondrial dynamics compared to control mice.
- - The findings suggest that Nkx2-1 and Pax8 mutations lead to neuroanatomical and neurochemical changes in the brain, highlighting potential targets for managing brain dysfunctions related to thyroid imbalances.
L. is a natural source of bioactive compounds that is already used for cosmeceutical and nutraceutical approaches. However, their phytochemical and antioxidant properties, although studied, have not been fully explored.
View Article and Find Full Text PDFBesides controlling several organellar functions, lysosomal channels also guide the catabolic "self-eating" process named autophagy, which is mainly involved in protein and organelle quality control. Neuronal cells are particularly sensitive to the rate of autophagic flux either under physiological conditions or during the degenerative process. Accordingly, neurodegeneration occurring in Parkinson's (PD), Alzheimer's (AD), and Huntington's Diseases (HD), and Amyotrophic Lateral Sclerosis (ALS) as well as Lysosomal Storage Diseases (LSD) is partially due to defective autophagy and accumulation of toxic aggregates.
View Article and Find Full Text PDFImpairment of both cellular zinc and redox homeostasis is a feature of several chronic diseases, including obesity. A significant two-way interaction exists between redox metabolism and the relatively redox-inert zinc ion. Redox metabolism critically influences zinc homeostasis and controls its cellular availability for various cellular functions by regulating zinc exchange from/to zinc-binding proteins.
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