Publications by authors named "L M Sutherland"
Influence of aqueous solutions of 2-(tetrafluoro(trifluoromethyl)-λ-sulfanyl-ethan-1-ol (CFSF-ethanol) on the stabilization of the secondary structure of melittin: comparison with aqueous trifluoroethanol using molecular dynamics simulations and circular dichroism experiments.
Phys Chem Chem Phys
January 2025
The influence of aqueous solutions of 2-(tetrafluoro(trifluoromethyl)-λ-sulfanyl-ethan-1-ol (CFSF-ethanol) and 2,2,2-trifluoroethanol (TFE) on the secondary structure of melittin was studied using circular dichroism (CD) and molecular dynamics (MD) simulations. In water, melittin transitions into a random coil. However, upon addition of even as little as 1% by volume of CFSF-ethanol, the secondary structure of melittin stabilizes as a helix.
View Article and Find Full Text PDFIntroduction: No clear guidelines exist for unfractionated heparin (UFH) monitoring in adult patients on veno-arterial extracorporeal life support (VA-ECLS) for refractory cardiogenic shock. In this study, we sought to compare outcomes between anti-factor Xa (FXa) and activated partial thromboplastin time (aPTT) strategies for UFH monitoring during VA-ECLS.
Methods: This is a single-center, retrospective review of VA-ECLS patients who received UFH in the cardiothoracic intensive care unit between July 2019 and November 2023.
Article Synopsis
- The northern North American Cordillera is a crucial area for biodiversity, particularly for unique lichens like the endangered wanderlust lichens which thrive in arid steppe habitats across several western states.
- The study focuses on understanding the evolutionary background and geographic distribution of these lichens (Rhizoplaca species) by analyzing their genetic information and using species distribution models.
- Findings indicate distinct genetic lineages linked to geographic regions, highlighting the importance of both dispersal and historical separation in the evolution of these lichens.
Article Synopsis
- The study looked at how to manage blood thinners after people got a special heart device called HeartMate 3.
- It compared two methods for checking the right dose of a blood thinner called unfractionated heparin (UFH).
- There were no big differences in bleeding or clotting problems between the two methods, but more research is needed to know which one is better.
Background: Metformin is a hypoglycaemic medication that has been proposed to treat or prevent preeclampsia. Combining national birth data from Scotland and Sweden, we investigated whether metformin used during pregnancy was associated with an altered risk of developing a hypertensive disorder of pregnancy.
Methods: We utilised data from two population-based cohorts: Scotland (2012-2018) and Sweden (2007-2019).