Publications by authors named "L M Sollid"
Article Synopsis
- Multiple sclerosis (MS) and coeliac disease share similar genetics, with a key role for a gene called HLA in both illnesses.
- Just like how eating gluten affects people with coeliac disease, the Epstein-Barr virus (EBV) is believed to play a big part in causing MS.
- Researchers think studying how coeliac disease works might help us understand MS better, and they consider using treatments against EBV to help people with MS, similar to how a gluten-free diet helps those with coeliac disease.
Recent reports have highlighted that beer labelled "gluten-free", crafted with enzymatic treatments to remove gluten, may contain polypeptides that could be immunotoxic to individuals with coeliac disease. As strict adherence to a gluten-free diet is the only way to manage this condition, accurate labelling is crucial to those with coeliac disease. This paper aims to discuss the presence, levels and immunogenicity of gluten peptides found in gluten-reduced barley beers.
View Article and Find Full Text PDFBackground And Aims: Development of novel treatments for celiac disease is dependent on precise tools to monitor changes in gluten-induced mucosal damage. Current histology measures are subjective and difficult to standardize. Biopsy proteome scoring is an objective alternative to histology which is based on robust changes in biological pathways that directly reflect gluten-induced mucosal damage.
View Article and Find Full Text PDFArticle Synopsis
- In vitro models studying autoimmunity often lack the complex immune environment and epithelial interactions necessary for accurate research, particularly regarding coeliac disease (CeD), which involves gluten triggering immune responses.
- Researchers created air-liquid interface (ALI) duodenal organoids from biopsies, preserving both epithelial cells and local immune cells, allowing for a more realistic study of CeD.
- The findings highlighted that gluten peptides led to significant epithelial damage in CeD organoids, mediated by immune responses including the action of IL-7, a critical factor in the disease's pathology, especially in active cases compared to those on gluten-free diets.
Background & Aims: This study aimed to determine the total prevalence of celiac disease (CeD), including undiagnosed cases, in a population-based study of adults screened for CeD.
Methods: The study used the fourth Trøndelag Health Study (HUNT4), conducted in 2017-2019, where 56,042 adult (aged >20 years) residents of Nord-Trøndelag County, Norway, participated. Serum samples from 54,505 participants were analyzed for anti-transglutaminase 2 IgA and IgG.