Social Media and Orthopaedics: Establishing Your Online Reputation.

With the rise of internet and social media usage in the 21st century, patients have increasingly been looking to online resources for information regarding their health care. It is imperative for physicians to recognize the trends and role of these tools in clinical orthopaedic practice, and to harness these tools to educate users, connect with other physicians, and interact with current and potential patients. It is important to review the current literature regarding social media in orthopaedics; some commonly used social media platforms and their individual characteristics; and general guidelines for creating content and managing an online reputation.

Molecular signatures associated with venous thromboembolism in children with acute lymphoblastic leukemia.

Background: Venous thromboembolism (VTE) is a frequent complication of childhood acute lymphoblastic leukemia (ALL).

Objectives: We aimed to identify molecular markers and signatures of leukemia microenvironment associated with VTE in childhood ALL, by dual-omics approach of gene expression (GEP) and DNA-methylation profiling.

Patients/methods: Eligible children were aged 1-21 years old with newly diagnosed ALL enrolled on the Dana Farber Cancer Institute 16-001 trial with available RNA sequencing data from bone marrow at diagnosis.

Feasibility of Utilizing a Brief Neurocognitive Battery in 3-Year-Old Patients During Treatment for Acute Lymphoblastic Leukemia.

Treatment of acute lymphoblastic leukemia (ALL) is associated with neurocognitive deficits in young children. While computerized measures have been utilized in pediatric oncology research, they exclude patients below the age of 4 years. Patients enrolled on "Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents" were offered participation in an optional neurocognitive study.