[Insulin function in rats at early terms after 4 Gy whole-body irradiation].

In the present study we made an attempt to estimate changes of insulin function at early terms after external irradiation of rats. Experimental conditions: male albino rats were studied 7; 14; 21; 28 days after the external whole-body gamma-irradiation (137Cs; 4 Gy). For this purpose the kinetics of 125I-insulin disappearance from blood plasma was investigated.

[Concentration of T3 and T4 in blood of non-irradiated and irradiated with different doses rats fasted for two days beforehand].

There were no changes in concentration of T3 and T4 in blood of the rats that were irradiated with a dose of 0.5, 1, 2, 4 and 6 Gy in comparison with non-irradiated rats, if the animals were not fed for two days before decapitation. This suggests that the effect of ionizing radiation on thyroid function is mediated by anorexia syndrome.

[Dynamics of changes in the concentration of thyroid hormones in in rat blood after subtotal thyroidectomy, internal, or external irradiation].

Thyroidectomy or administration of high activities (> 1.1 Mbq) of 131I to rats causes initial decrease in blood concentration of thyroid hormones which returns to the normal level. Administration of lower doses (< 1.

[Dynamics of thyroxine and triiodothyronine concentration in the rat blood at early times after subtotal removal of the thyroid gland or under effects of different I-131 action].

The alterations of amount of thyroid hormones have the characteristic dynamics that manifest itself by initial reduction with following partial or complete restoration of T3 and T4 concentration in rat blood after surgical or radioactive injuries of thyroid gland. Through presence of threshold of several dozens Gy for early dose-dependent hypothyroidism, the thyroid gland seems to be relatively radioresistant organ. Thyroid hormones concentration in blood has restored to normal level after experimental injuries which shows high restoration potential of thyroid gland function.

[A modified method of isolation of Langerhans islets from the rat pancreas].

A simple procedure is developed for isolation of Langerhans islands (LI) from rat pancreas. Homogenization of pancreatic tissue was carried out using two "Record" syringes equipped with needles of various diameter. Collagenase was not used in the procedure.